1. Stojko Vidovic, Medicinski fakultet Banja Luka ,
Republic of Srpska, Bosnia and Herzegovina
2. Jelena Bećarević , Medicinski fakultet Banja Luka ,
Republic of Srpska, Bosnia and Herzegovina
3. Vanja Vidović, Medicinski fakultet Banja Luka ,
Republic of Srpska, Bosnia and Herzegovina
Background: Fatty acid-binding protein 2 (FABP2) is primarily involved in the intestinal absorption and intracellular transport of long-chain fatty acids. The rs1799883 polymorphism is associated with increased fatty acid binding affinity, which may contribute to atherogenic dyslipidemia and cardiovascular risk.
Aim: To investigate the association of the FABP2 polymorphism with lipid profile parameters and selected cardiometabolic risk factors in patients with acute myocardial infarction (AMI).
Methods: A cross-sectional observational study included 190 patients with acute myocardial infarction. FABP2 rs1799883 genotyping was determined by qPCR.
Results: The distribution of FABP2 rs1799883 genotypes was 45.8% CC, 47.4% CT, and 6.8% TT. Allele frequencies were 69.5% for the C allele and 30.5% for the T allele, with genotype distribution consistent with Hardy-Weinberg equilibrium (χ²=2.59, p=0.1075). A statistically significant association was observed between FABP2 genotypes and serum LDL cholesterol levels (p=0.0231). TT homozygotes exhibited the highest LDL cholesterol concentrations, followed by CT heterozygotes and CC homozygotes. Total cholesterol showed a non-significant trend toward higher values in TT carriers (p=0.0958). Furthermore, FABP2 genotypes were significantly associated with smoking status (p = 0.0260), with a higher prevalence of smokers among T allele carriers than among CC homozygotes. A significant association was also found with sex distribution (p = 0.0399), with the TT genotype showing a higher proportion of females compared with the CT and CC genotypes.
Conclusion: The FABP2 rs1799883 polymorphism was significantly associated with elevated LDL cholesterol levels in patients with acute myocardial infarction. Homozygosity for the T allele was associated with the highest LDL cholesterol concentrations, suggesting a potential contribution of this genetic variant to an atherogenic lipid profile. These findings suggest that FABP2 genetic variation may contribute to lipid metabolism disturbances and cardiovascular risk in patients with acute myocardial infarction.
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Datum:
29.07.2026.
Contemporary Materials 2026 - Savremeni Materijali
