1. Biljana Gatarić, Medicinski fakultet Banja Luka ,
Republic of Srpska, Bosnia and Herzegovina
2. Anđelka Račić, Medicinski fakultet Banja Luka , Republic of Srpska, Bosnia and Herzegovina
3. Nataša Bubić Pajić, Medicinski fakultet Banja Luka , Republic of Srpska, Bosnia and Herzegovina
Many drugs have potential to interact with alcohol at a pharmacodynamics and pharmacokinetic level resulting in potentially serious medical consequences. Also, ethanol can act as a cosolvent and increase dissolution rate and apparent solubility in gastointestinal fluids. The aim of this study was to determine how the presence of ethanol influence in vitro release of five drugs. In vitro dissolution tests were carried out in two phases using appropriate pharmacopoeial methods. In the first phase, aqueous buffered solution was used as a dissolution medium. In the second phase, 20 % (v/v) of the medium was replaced with ethanol. Dissolution profile was not affected by alcohol only in the case of diazepam tablets, while alcohol changed the dissolution profiles obtained for acetaminophen, acetylsalycilic acid, ibuprofen tablets and ketoprofen capsules as well. However, the amount of the drug dissolved at the end of the experiment were significantly increased by ethanol addition for all investigated samples, with the exeption of diazepam tablets, where the amount of drug dissolved (%) was decreased. Since ethanol increased pH of the dissolution media, higher drug amounts (%) were expected in the case of acidic drugs. Therefore, the presence of alcohol may affect drug absorption and consequently its bioavailability and therapeutic outcome.
Ključne rečitestttt :
SIMPOZIJUM B - Biomaterijali i nanomedicina