1. Miloš Mirović, Serbia
Introduction: Regarding the potential role of vitamin D in immune system regulation, association between vitamin D and autoimmune diseases is a matter of investigation.
The aim: We evaluated association between the level of vitamin D and biochemical markers of thyroid autoimmunity in patients with Hashimoto`s thyroiditis.
Material and Methods: 35 patients with previously diagnosed Hashimoto`s thyroiditis (mean age 43,46 ± 13,79 years) were included in this study. 20 healthy, euthyroid, age and sex matched subjects were included in control group. Blood sample were taken from all the participants in order to measure concentration of FT3, FT4, TSH, anti-TPOAb, anti-TgAb and total 25(OH)D. All the results were statistically processed by statistical package Data Analysis.
Results: Concentration of FT3 (4.12vs.4.58; p<0.01) and FT4 (12.42vs.13.40; p<0.05) were significantly lower, but concentration of TSH was significantly higher (8.54vs.1.58; p<0.01) in patients with Hashimoto`s thyroiditis than in control group. Statistically significant higher values of anti-TPOAb (807.58vs.0.57; p<0.01) and anti-TgAb (237.13vs.1.24; p<0.01), were observed in patients with Hashimoto`s disease compared to controls. Serum level of total 25(OH)D was significantly lower in Hashimoto`s patients than in controls (36.66vs.59.40; p<0.01). Significant negative correlation of total 25(OH)D with level of anti-TPOAb (r= -0.34; p<0.05) was observed in patients with Hashimoto`s thyroiditis.
Conclusion: Severity of 25(OH)D deficiency and the level of negative correlation of 25(OH)D level with anti-TPOAb in patients with Hashimoto`s thyroiditis may implicate a potential role of vitamin D deficiency in development of Hashimoto`s thyroiditis.
Ključne reči :
Tematska oblast:
Medicinske nauke
Datum:
12.10.2014.
7. Studenti u susret nauci sa međunarodnim učešćem, StES2014
