1. Olivera Klisurić, Univerzitet u Novom Sadu, Prirodno-matematički fakultet, Departman za fiziku, Serbia
2. Aleksandar Oklješa, Prirodno-matematički fakultet, Univerzitet u Novom Sadu, Trg Dositeja Obradovića 3, Novi Sad, Srbija, Serbia
Bearing in mind that androstane derivatives with tethered heterocyclic groups at position C17 show anticancer activity, the aim of this study was a synthesis of novel steroidal derivatives with a tetrazole ring as a substituent at C17 position, as well as a detailed investigation of their structures. The crystal structures of the two novel androstane derivatives: 3β-acetoxy-17-(1-methyl-1H-tetrazol-5-yl)androsta-5,16-diene (1) and 3β-acetoxy-17-(2-methyl-2H-tetrazol-5-yl)androsta-5,16-diene (2) were determined at room temperature. The compound 1 crystallizes in the monoclinic system, space group P21 with the unit cell parameters, a = 9.7390 (5), b = 7.3412 (3), c = 30.5185 (15) Å, = 96.970 (5)° and Z = 4. The final R factor is 0.059 for 7761 independent reflections and 547 parameters. The compound 2 crystallizes in the orthorombic system, space group P212121 with the unit cell parameters, a = 7.3721(2), b = 9.8807(2), c = 30.1493(9) Å and Z = 4. The final R factor is 0.041 for 4186 independent reflections and 267 parameters. Hirshfeld surface analysis of studied compounds was performed in order to identify close intermolecular contacts in crystals.
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Thematic field:
SIMPOZIJUM B - Biomaterijali i nanomedicina
Date:
01.08.2021.
Contemporary Materials 2021 - Savremeni materijali
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