1. Dušica Risović, 2. Zihret Abazi, Albania
EFFECT OF ACETAZOLAMIDE ON CENTRAL CORNEAL THICKNESS AFTER PHACOEMULSIFICATION IN SPECTRAL DOMAIN OPTICAL COHERENT TOMOGRAPHY
Abazi Zihret 1,Magarasevic Lidija 1,Stamenkovic Miroslav 1,Risovic Dusica 1,Gvozdenovic Ranko2
1. Zvezdara University Medical Center,Eye Clinic
2. School of Medicine, University of Belgrade
INTRODUCTION: Acetazolamide as inhibitors of carbonic anhydrase in glaucoma therapy has an effect on lowering intraocular pressure. In addition to this primary effects, we attempted to determine the effect on the cornea after phacoemulsification. In our study, we determined the effects of systemically applied dose of 250 mg of acetazolamide on the edema, thickness, and corneal morphology after phacoemulsification ,the spectral optical coherent tomography ,high resolution (HR SD-OCT).
MATERIALS AND METHODS: The study included 47 patients who were divided into two groups.Groups were stratified by type of cataract (nuclear), age (62 ± 1.5), preoperative visual acuity (5/60±0,05 on the Snellen table) and preoperative findings on HR SD-OCT. Phacoemulsification has worked the same surgeon, with the same ultrasound probe length using ultrasonic force for a period of 52 ± 2.5 seconds and the average value of 14. Group of 31 patients were administered systemic acetazolamide at a dose of 250 mg per scheme 01 hours +24 hours after phacoemulsification. Another group of 16 patients did not receive acetaztolamid.HR SD-OCT recordings were performed before surgery, 6 hours and 24 hours after surgery to all patients.
RESULTS: Before surgery the mean value in both groups was 556 ± 8 μm. Group I that received medication after 6h average value of 648 ± 6 μm, after 24 h mean value was 612 ± 4μm. The group that did not receive acetazolamide had a mean thickness of the cornea after 6 hours of 720 ± 5 μm, and after 24 hours 708 ± 4μm. Morphological changes in the tomograms of the group who received acetazolamide showed minimal creases Descemet's membrane. Postoperative visual acuity at 24h in the group receiving the drug was 0.6 ± 0.05, while the second group was 0.3 ± 0.05 on the Snellen table.
CONCLUSION: In our study where patients were administered systemic acetazolamide has been a significant reduction of central corneal thickness and to reduce postoperative corneal edema. The folds Descemet's membrane and endothelial dysfunction in HR SD OCT recordings in this group showed less structural changes. Significant postoperative visual acuity in these patients is probably caused by small corneal edema after 24 h, which improves patients' comfort and better postoperative results.
Ključne reči :
Tematska oblast:
cornea, kontaktna sočiva
Uvodni rad:
Da
Datum:
28.03.2012.
Br. otvaranja:
1052
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