1. Dušica Risović, 2. Zihret Abazi, Albania
THE ROLE OF HIGH RESOLUTION SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY IN CORNEAL DYSTROPHY AND DEGENERATION
Abazi Zihret 1,Magarasevic Lidija 1,Stamenkovic Miroslav 1,Risovic Dusica 1,Gvozdenovic Ranko2
1. Zvezdara University Medical Center,Eye Clinic
2. School of Medicine, University of Belgrade
Introduction: Spectral domain optical coherence tomography high-resolution (HR SD OCT) of the anterior segment is a relatively new noninvasive method which allows us a detailed overview of anatomical-structural changes of cornea. In our study, we have analyzed the morphological characteristics of changes in the cornea at the HR SD OCT with corneal dystrophy and degeneration. We compared the findings of HR SD OCT with a clinical presentation at the Slit lamp and tried to determine the role of HR SD OCT in the clinical evaluation of dystrophy and degeneration of the cornea.
Materials and methods: A prospective study in 15 patients divided into two groups. Group of 8 patients had clinically verified changes on cornea. In 6 patients were dystrophy,three cases of stromal dystrophy and one case of corneal endothelial dystrophy,and 2 patients with epithelial dystrophy. Two patients had degenerative changes in the cornea. The control group included 7 patients without clinical signs of changes on cornea. Clinical examination was performed at the Slit lamps, a HR SD OCT tomograms (SOCT Copernicus HR) in asteriks cross sections of 3μm, width 4mm and 5 mm. Software analysis was assessed structural distribution, size, density, and accumulation within the changes.
Results: In Slit lamp it could not be determined with great certainty the deposit accumulation layer in boundary forms which extend through Bowmanov layer and penetrate the epithelium. On HR SD OCT tomograms like as histopathologic findings can reliably determine structural arrangement, the spatial relationship of mutual deposit. Based on the intensity of the reflection light beam at the HR SD OCT we have determined a different consistency of the deposit, which has the highest accumulation in their central part. Measuring at the HR SD- OCT we have determined the size and spatial distribution of each individual deposit. In the control group there was no structural changes, with clearly differentiated anatomical layers of the cornea.
Conclussion: The role of HR SD OCT on the anterior segment is extremely important for dystrophy and degeneration of the cornea because it allows us to analyze structural changes. HR SD OCT as noninvasive method may represent in vivo optical biopsy and essential part of the clinical evaluation of dystrophy and degeneration of the cornea. As in their distribution also in the size and compactness of the deposit. This significance may have important clinical significance in planning of any surgical procedure, because the spatial distribution and accumulation places can be mapped preoperatively.
Ključne reči :
Tematska oblast:
cornea, kontaktna sočiva
Uvodni rad:
Da
Datum:
30.03.2012.
Br. otvaranja:
777
Datoteka uz rad
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