1. Mohamed Ramadan Mahmoud Mahmoud
Abstract Purpose To study the effect of topical non steroidal anti inflammatory drugs (NSAIDs) in high risk diabetic patients undergoing cataract surgery in preventing cystoid macular oedema (CME). Setting: El Moada Eye Hospital, Shebin El Kom, Menoufiya, Egypt. Methods: 86 eyes of 70 diabetic patients with high risk characteristics for development of CME were randomized to receive NSAIDs (ketorolac 0.4%) for 12 weeks after phacoemulsification with foldable IOL implantation or not. Those patients were divided into 2 groups, group (A) (43 eyes) were given topical NSAIDs, and group (B) (43eyes) not given topical NSAIDs. The incidence and severity of CME were evaluated by fluorescin angiography, retinal foveal thickness on optical coherent tomography. Results: -for group (A), only one eye developed CME, and for group (B), 10 eyes developed CME, and hence there was high significant difference in the incidence of CME between the two groups (P= 0.004) - In group (A), the eye which developed CME had retinal foveal thickness of 260 μm, while in group (B), the mean retinal foveal thickness was 338.5±91.86 μm (range 220-495 μm) at 12 weeks postoperatively. Conclusion NSAIDS may have a fundamental role in prevention of CME in high risk diabetics undergoing cataract surgery. However, the results are limited in the small number of patients enrolled in this study, long term toxicity of topically applied drugs, and uncertain patient reliability.
Ključne reči :
Tematska oblast:
medical retina
Uvodni rad:
Da
Datum:
30.03.2012.
Br. otvaranja:
733
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