Designe:
Purpose : To present 23 cases with conjunctival and corneo-conjunctival neoplasia treated with mitomycin C and Interferon α -2b
Material and Methods: Prospective ,nonrandomise, noncomaprative, interventional study. Of all cases with conjunctival or corneo-conjunctival neoplasia treated with local and topical application of Mitomicin- C and Interferon α -2b at the Eye Clinic Sarajevo in the period of 2005 to 2011, 23 cases (with reference to inclusion and exclusion criteria) were included in this study .
Group I : 12 cases with melanotic lesions
Group II: 11 cases with non melanotic neoplasia of conjunctivae or corneo-conjunctive.
All patients had macroscopic ( biomicroscopic ) appearance of conjunctival or corneo-conjunctival neoplasia.Confirmation of diagnosis was achived by patohistological analysis of samples of impression citology and /or after patohistological analysis of material obtained by excisional biopsy.
Results : Of 23 cases in 9 cases tumors disapeared after 3 cycles of local and topical treatment with MMC and Interferon α -2b. In 12 cases ( after 3 cycle of antimetabolites) tumors were smaller( chemoreduction ) or unchanged and required additional surgical treatment with cryoaplication. In two cases tumor enlarged after antimetabolite treatment. Three cases with intensive vascularisation treated and with local application of bevacizumab.
Patohistological results (impression cytology or excisional biopsy) : 8 cases had malignant melanotic melanoma, 2 case amelanotic melanoma, 2 cases had primary acquired melanosis. In 9 cases was confirmed squamocellular carcinoma, one had intraepithelial neoplasm G3,one case had planocellular carcinoma.
Conclusion: Excision with cryotherapy are still standard treatment of conjunctival neoplasia.In selected cases, antimetabolite, may be therapeutic options for the treatment of conjunctival and/or corneo- conjunctival neoplasia as permanent solution, or as chemoreduction before surgical excision and cryotherapy. Because of their simple requirements ( of imprssion cytology and simple requirements for antimetabolites application ) both procedures can be used in outpatients settings.
Кључне речи :
Тематска област:
cornea, kontaktna sočiva
Уводни рад:
Да
Датум:
12.04.2012.
Бр. отварања:
534
