Introduction:
Despite the efforts made to achieve early detection, effective and successful treatment of malignant diseases, adjuvant therapy has become increasingly popular to provide better results and reduction the mortality rates from cancer. In Europe, extracts from Viscum album, the European white-berry mistletoe, are widely used as alternative treatment for patients with cancer. On the whole mixture of active components in the aqueous solution of white mistletoe, antineoplastic strongest potential has lectin.
The aim:
The purpose of this paper is to prove the antitumor effect of lectin from mistletoe extract on white Wistar rats with stimulation of immune system by increasing the number and activity of varios types of white blood cells.
Material and methods:
The three groups of mice (5 mice / group) was placed on the 4 day semi-synthetic diet. All mice were treated subcutaneously with melanoma cells (B16F10 cells). One group served as placebo control group, that is not treated with lectins and the rest were treated with ML-1 with a daily dose of lectin to 1,0 ng/kg (this is experimental number becose we have aqueous solution of plant). The examination is worked over 9 days.
Results:
After 72 hours of treatment with lectin cytotoxicity of NK cells doubles and the number of granulated lymphocytes increased three times compared with the untreated control group.
Conclusions:
From the analysis and results we can conclude that the lectin acts stimulating the immune system (immune modulation) perform stabilization of DNA in white blood cells, stimulate an increase in the number and activity of certain types of leukocytes. Lektin induces macrophage cytotoxicity, phagocytosis, then increasing cytokine secretion in vivo (TNF-alpha, IL-1, IL-2, IL-6).
Тематска област:
Медецинске и здравствене науке
Датум:
23.10.2012.
Бр. отварања:
478
5. naučno-stručni skup Studenti u susret nauci sa međunarodnim učešćem - STES
