1. Irena Kasagić-Vujanović,
Republic of Srpska, Bosnia and Herzegovina
2. Nina Okuka, Medicinski fakultet Banja Luka ,
Republic of Srpska, Bosnia and Herzegovina
3. Darija Knežević,
Republic of Srpska, Bosnia and Herzegovina
Lisinopril is an antihypertensive drug from the ACE inhibitor group. It is often used in practice and, in oral administration, is characterized by very low percentage of resorption (~25%). Therefore, it is important to ensure the stability of this drug, since any degradation leads to a
decrease in the percentage of resorption and an increased risk of sub-dosage of patients. In accordance with modern trends, the chemical stability of lisinopril under the influence of various aqueous media was tested: distilled water, 0.1M HCl, 0.1M and 0.01M NaOH and 3% hydrogen peroxide solution. In order to clearly define the effect of elevated temperature on the stability of this drug, tests were carried out at 25°C and 50°C. High-pressure liquid chromatography was used as the method. The obtained results clearly define that lisinopril is the most sensitive to hydrolysis in the base environment, where at 25°C, in the first minute, it degrades ~ 100%. In this paper, kinetic parameters (degradation constant rate, the half-life of degradation and activation energy) were also determined, which enabled clear definition of the stability and degradation profile of lisinopril under the influence of various stress agents. In the degradation of lisinopril in neutral and acidic medium, impurity D is identified as the main degradation product.
Thematic field:
SIMPOZIJUM B - Biomaterijali i nanomedicina
Date:
11.10.2017.
Contemporary Materials 2017 - Savremeni Materijali
